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KMID : 1005420180200020112
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Journal of Cerebrovascular and Endovascular Neurosurgery
2018 Volume.20 No. 2 p.112 ~ p.119
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The Prevalence and Characterization of Cerebral Microbleeds in Young People Having Intracerebral Hemorrhage
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Lee Young-Min
Koo Hae-Won
Kang Hyung-Koo
Kim Jin-Woo
Han Seong-Rok
Yoon Sang-Won
Choi Chan-Young
Sohn Moon-Jun
Lee Chae-Heuck
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Abstract
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Objective : Cerebral microbleeds (CMBs) are known as the neuroimaging markers of risk in stroke and dementia. Many studies on CMBs in elderly patients with hemorrhagic or ischemic stroke have been reported; however, reports on CMBs in young populations with intracerebral hemorrhage (ICH) are lacking.
Materials and Methods : A total of 272 patients aged 18-54 years presented to our hospital with ICH between December 2009 and August 2017. Among these, CMB presence, count, and topography with respect to ICH were evaluated on magnetic resonance imaging (MRI) gradient echo images (GREs). We also evaluated the prevalence and risk factors of CMBs.
Results : Among 272 patients, only 66 underwent GRE T2-weighted MRI. CMBs were detected in 40 patients (61%), with 29 (73%) being of the multifocal type. Among the 219 CMBs, 150 (68.5%) were of the deep type and 69 (31.5%) of the lobar type. CMB prevalence was higher in men. In multivariate logistic regression analysis, history of hypertension (adjusted odds ratio [aOR], 4.048; 95% confidence interval [CI], 1.14-14.32; p = 0.030), and male sex (aOR, 4.233; 95% CI, 1.09-16.48; p = 0.037) were independently associated with CMBs.
Conclusion : In young patients who presented with spontaneous ICH, CMBs were highly prevalent in 61% of patients and strongly associated with history of hypertension and male sex.
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KEYWORD
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Cerebral microbleeds, Intracranial hemorrhage, Risk factors, Young adult
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